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The reign of Roman disease: why did disease hit a flourishing empire?

The Roman empire is just one example through history that shows how social progress has long had a complicated relationship with the spread of disease. Dr Kyle Harper explained more on the HistoryExtra podcast…

An allegorical depiction of the plague in ancient Rome, an angel batters down a door while people lie sick on the ground
Published: October 8, 2021 at 1:23 pm
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Dirty and disgusting diseases… you might think it would be struggling civilisations that have been the most affected by infectious outbreaks, but throughout history it’s actually those that were flourishing that were hit the worst. It may seem somewhat paradoxical for germs to benefit from our success, but according to Dr Kyle Harper, historian of ancient Rome and author of a new global history of diseases, this isn’t the case. Speaking on the HistoryExtra podcast, Harper told us more about the causes of the spread of disease in ancient Rome.


The second century AD, says Harper, could be considered the height of the Roman empire – what historian Edward Gibbon has famously called the “happiest age”. With a booming population, mass urbanisation and trade links stretching out from Africa to East Asia bringing in aromatics, spices and silks, the empire was flourishing. But, around this time, it also faced many outbreaks of infectious diseases, including the infamous Antonine Plague (165–80 AD), also known as the Plague of Galen. We know that major pandemics such as this were a powerful factor in influencing Roman history.

Yet the combination of illness and success strikes a strange note. Harper argues that we should consider history from the ecologist’s point of view, seeing how pandemics have affected us and emphasising how our actions have affected them. Doing so can reveal how progress has long had a complicated relationship with disease. Unlike what might be expected, disease outbreaks do not just occur because a society is in crisis, or because of misery and trouble.

Disease can also thrive as a result of conditions of human social development. The great diseases of the world are, in a sense, evolutionary responses to the way we live, says Harper, and have changed the physical environment around us. They are caused by agents or microparasites (usually either bacteria, fungi, protozoa or viruses). These are rewarded, argues Harper, “if they happen to be good at getting energy or taking over cells and passing their genes on to future generations”. These parasites benefit when their host benefits; when humans multiply and travel, it creates opportunities for them.

Not only did the increasing population size and the urbanisation of the Roman empire mean that there were great numbers of people sharing air, water and sewage space, but the large size and interconnectedness of the empire created the perfect conditions for the population to be exposed to new pathogens and for disease to spread rapidly. With the Roman empire facing such success, outbreaks were bound to happen.

You can hear the full conversation with Kyle Harper, which covers the sprawling global history of infectious diseases, on the HistoryExtra podcast:

Kyle Harper is the author of Plagues Upon the Earth: Disease and the Course of Human History (Princeton, 2021)



Emily BriffettPodcast editorial assistant

Emily is HistoryExtra’s podcast editorial assistant. Before joining the BBC History team in 2021, Emily graduated with an MA in Public History from Royal Holloway, University of London


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